CBD Store Basics: What is the Endocannabinoid System?

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As a CBD store, we make it a point to understand the science of CBD. The endocannabinoid system (ECS) is a fascinating and intricate part of human physiology, influencing a variety of processes from mood to appetite. This system has come under increased scrutiny and interest with the rise in popularity of cannabis-derived compounds such as cannabidiol (CBD) and tetrahydrocannabinol (THC).

The Basics of the ECS & How our CBD Store Products Relate

At its core, the ECS consists of:

1. Endocannabinoids: These are naturally produced lipid-based retrograde neurotransmitters in the body. Anandamide (AEA) and 2-arachidonoylglycerol (2-AG) are two primary endocannabinoids.

2. Receptors: Mainly the CB1 and CB2 receptors. CB1 receptors are primarily found in the central nervous system (CNS), whereas CB2 receptors are more prevalent in peripheral organs, especially immune cells.

3. Enzymes: Responsible for the synthesis and degradation of endocannabinoids. Two primary enzymes include fatty acid amide hydrolase (FAAH), which breaks down AEA, and monoacylglycerol acid lipase, which degrades 2-AG.

How does it function?

The ECS is involved in regulating a range of physiological processes including appetite, pain, mood, memory, and immune system responses. Endocannabinoids can bind to either CB1 or CB2 receptors, creating effects that depend on the receptor type and location in the body. In general, the ECS acts as a bridge between the body and the brain, providing feedback and regulation. It’s this bridge that makes our CBD store so successful!

Image from Harvard Health article on the Endocannabinoid System. Read more here.

Interaction with THC and CBD

• THC (Tetrahydrocannabinol): It is the main psychoactive component of cannabis. THC binds directly to the CB1 receptors, which are abundant in the brain. This binding mimics the action of endocannabinoids but with a stronger effect, leading to the characteristic “high” associated with marijuana consumption. By stimulating the CB1 receptor, THC can influence memory, mood, perception, and appetite.

• CBD (Cannabidiol): Unlike THC, CBD doesn’t bind strongly to either CB1 or CB2 receptors. Instead, it’s believed that CBD may prevent the breakdown of endocannabinoids by inhibiting the action of certain enzymes. This leads to increased levels of endocannabinoids in the system. Products like from our CBD store may also influence other receptors in the body, such as serotonin receptors, contributing to its potential therapeutic effects on mood and anxiety.


The endocannabinoid system is a crucial part of our body’s ability to maintain homeostasis. While research into the ECS and its interactions with compounds like THC and CBD is ongoing, it’s clear that understanding this system holds the key to unlocking the potential therapeutic uses of cannabis and its derivatives. As science delves deeper, we can expect even more insights and applications in the realm of health and well-being – and as your friendly neighbor CBD store, we’ll be sure to keep you updated!

You can explore our raised in NC, locally made and independently tested CBD Store products here.

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